The contact called on behalf of her husband who owns a 2020 Ford F-250. The contact stated that while her husband was driving on the highway at 70 MPH, the vehicle stalled, with the Low Power Mode message displayed, and within 3-5 seconds there was a large cloud of smoke coming from the front end of the engine bay, and the vehicle proceeded to slow down. The driver pulled over onto the side of the highway. The vehicle was not able to be restarted; however, while attempting to restart the vehicle there was an abnormal knocking sound coming from the engine. The vehicle was towed to a local dealer where the vehicle was diagnosed. The contact was advised that the high-pressure fuel pump was faulty and had exploded, causing metal shards to enter the engine. The contact was informed that the engine and the fuel pump needed to be replaced. The vehicle was not repaired. The manufacturer was notified of the failure. The approximate failure mileage was 175,000.